Oral ulcerations as a sequela of tacrolimus and mycophenolate mofetil therapy.
Publication/Presentation Date
12-1-2014
Abstract
Medication-induced ulcerative stomatitis can be a complication of immunosuppressive therapy in a post-transplant patient. A 54-year-old African-American female patient presented with significant, recalcitrant oral ulcers 5 months after renal transplant as a result of mucosal toxicity and severe leucopenia caused by her immunosuppressive maintenance regimen of tacrolimus (US Pharmacopeia, Rockville, MD) and mycophenolate mofetil (Santa Cruz Biotechnology, Santa Cruz, CA). The patient was also prescribed fluconazole as an antifungal, which likely contributed to the patient's increase in tacrolimus blood levels. Altering the medication dosages ultimately reduced blood tacrolimus levels, allowing for resolution of her oral ulcers. This report indicates that medication-induced oral ulcerations are a potential sequela of post-transplant immunosuppressive therapy.
Volume
118
Issue
6
First Page
175
Last Page
178
ISSN
2212-4411
Published In/Presented At
Philipone, E., Rockafellow, A., Sternberg, R., Yoon, A., & Koslovsky, D. (2014). Oral ulcerations as a sequela of tacrolimus and mycophenolate mofetil therapy. Oral surgery, oral medicine, oral pathology and oral radiology, 118(6), e175–e178. https://doi.org/10.1016/j.oooo.2014.08.018
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
25457894
Department(s)
Department of Anesthesiology
Document Type
Article