Effect of clonidine premedication on haemodynamic responses to fibreoptic bronchoscopy.
Publication/Presentation Date
3-1-2000
Abstract
The usual haemodynamic response to fibreoptic bronchoscopy is an increase in heart rate and blood pressure. We therefore compared, in a prospective, randomised, double-blind study, the effect of two doses of oral clonidine premedication (150 microg or 300 microg) with placebo (control group) on the haemodynamic alterations in 62 patients who underwent elective fibreoptic bronchoscopy. Significant increases in blood pressure and heart rate were observed during fibreoptic bronchoscopy only in the control group. Clonidine 150 microg blunted the haemodynamic response to fibreoptic bronchoscopy (p < 0.05). Significant decreases in systolic blood pressure (< 90 mmHg) were observed in all patients premedicated with 300 microg clonidine. Throughout the study nine patients (75%) in the 300 microg clonidine group were treated at least once for hypotension. Compared with the control group, time to awakening was significantly longer only in patients premedicated with 300 microg clonidine. In conclusion, premedication with 150 microg oral clonidine attenuates haemodynamic responses to fibreoptic bronchoscopy, without causing excessive haemodynamic depression and sedation. These data encourage the administration of clonidine as premedication in patients undergoing fibreoptic bronchoscopy, particularly in those with, or at risk for, coronary artery disease.
Volume
55
Issue
3
First Page
269
Last Page
274
ISSN
0003-2409
Published In/Presented At
Matot, I., Kuras, Y., & Kramer, M. R. (2000). Effect of clonidine premedication on haemodynamic responses to fibreoptic bronchoscopy. Anaesthesia, 55(3), 269–274. https://doi.org/10.1046/j.1365-2044.2000.01215.x
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
10671847
Department(s)
Department of Anesthesiology
Document Type
Article