Comparisons between the antianesthetic action of dibutyryl cyclic AMP and analeptic drugs on amobarbital-induced narcosis in the rat.
Publication/Presentation Date
1-1-1976
Abstract
The dose-related antianesthetic and antidotal property of dibutyryl cyclic AMP, devoid of toxic effects, imparts uniqueness to the nucleotide as an arousal agent. Of the analeptic drugs studied (d-amphetamine, picrotoxin, pentylenetetrazol, caffeine, theophylline, strychnine, ethamivan and doxapram), only picrotoxin demonstrated antianesthetic properties. However, picrotoxin was associated with severe toxicity at all dose levels tested. No analeptic drug is effective in reversing the central nervous system depression produced by sedative, hypnotic or tranquilizer drug overdosage.
Volume
14
Issue
1
First Page
39
Last Page
46
ISSN
0031-7012
Published In/Presented At
Kraynack, B. J., Cohn, M. L., Cohn, M., & Taylor, F. H. (1976). Comparisons between the antianesthetic action of dibutyryl cyclic AMP and analeptic drugs on amobarbital-induced narcosis in the rat. Pharmacology, 14(1), 39–46. https://doi.org/10.1159/000136577
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
8796
Department(s)
Department of Anesthesiology
Document Type
Article