Effects of lipoxygenase inhibitors in arachidonate-induced sudden death.
Publication/Presentation Date
3-1-1984
Abstract
Both BW 755c, a cyclo-oxygenase and lipoxygenase inhibitor, and nordihydroguaiaretic acid (NDGA), a selective lipoxygenase inhibitor, were tested for their protection against arachidonate-induced sudden death in rabbits. 100% survival was seen with BW 755c (1 mg kg-1), while NDGA showed 0 and 17% survival (2 mg kg-1 and 4 mg kg-1). BW 755c prevented 12-fold increase in plasma thromboxane B2 concentrations and the formation of pulmonary artery thrombi normally seen with arachidonate-induced sudden death, while NDGA showed no such protective effect. Radioimmunoassay of rabbit plasma for leukotrienes (LTC4, LTD4 and LTE4) indicated that they do not accumulate in blood in the model and BW 755c had no effect, suggesting that the deleterious effects seen are caused by cyclo-oxygenase pathway metabolites such as thromboxane A2, but not by lipoxygenase pathway products such as leukotrienes.
Volume
36
Issue
3
First Page
205
Last Page
207
ISSN
0022-3573
Published In/Presented At
Roth, D. M., Feduska, R., Lefer, A. M., & Smith, J. B. (1984). Effects of lipoxygenase inhibitors in arachidonate-induced sudden death. The Journal of pharmacy and pharmacology, 36(3), 205–207. https://doi.org/10.1111/j.2042-7158.1984.tb06943.x
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
6144761
Department(s)
Department of Anesthesiology
Document Type
Article