Use of Positron Emission Tomography to Measure Brain Activity Responses to Fentanyl Analgesia.
Publication/Presentation Date
1-1-1999
Abstract
This review illustrates the potential of positron emission tomography (PET) in elucidating the supraspinal analgesic mechanisms of opioids in humans. First, a range of PET methodologies, available for functional brain mapping both on the receptor and neuronal network level in humans, is examined briefly. Subsequently, studies that have taken advantage of only a small portion of these PET techniques are reviewed. In light of the limitations of these experiments, a series of strategies is discussed that, by exploiting the full arsenal of PET techniques, could provide unique insights into the supraspinal mechanisms of opioid analgesia under the clinically most relevant circumstances--in the living human brain.
Volume
3
Issue
5
First Page
359
Last Page
366
ISSN
1069-5850
Published In/Presented At
Kurata, J., Gyulai, F. E., & Firestone, L. L. (1999). Use of Positron Emission Tomography to Measure Brain Activity Responses to Fentanyl Analgesia. Current review of pain, 3(5), 359–366. https://doi.org/10.1007/s11916-999-0078-x
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
10998692
Department(s)
Department of Anesthesiology
Document Type
Article