The Effect of Sedation on Long-Term Psychological Impairment After Extracorporeal Life Support.
Publication/Presentation Date
3-1-2020
Abstract
OBJECTIVE: This retrospective study aimed to identify the association between long-term psychological impairment and total sedation received during venovenous extracorporeal life support (VV-ECLS) for acute respiratory failure (ARF).
DESIGN: This observational retrospective study compared characteristics between patients with and without long-term psychological morbidity at long-term follow-up after VV-ECLS for ARF.
SETTING: A single institutional experience in a quaternary referral academic medical center in the United States.
PATIENTS: Patients who received VV-ECLS for ARF between January 1, 2015, and April 1, 2017, were identified for selection. Presence of psychiatric morbidity (anxiety and/or depression) was determined with the Hospital Anxiety and Depression Subscale battery at long-term follow-up.
INTERVENTIONS: No interventions were made during this retrospective observational study.
MEASUREMENTS AND MAIN RESULTS: A total of 42 patients (21 male, 21 female, median age 49 [interquartile range {IQR} 36-57]) completed a telephone interview a median of 14.6 (IQR 7.7-21.1) months after ECLS decannulation. Cohorts were defined as possessing any psychiatric morbidity (anxiety and/or depression) as defined by the Hospital Anxiety and Depression Subscale battery (n = 22 [52%]) versus no psychiatric morbidity (n = 20 [48%]) at long-term follow-up. Patients who had clinically significant psychiatric morbidity received a median of 15.0 (IQR 11.0-17.0) days of continuous intravenous sedation compared with patients who had no psychiatric morbidity, who received a median of 10.0 (IQR 6.5-13.5) days of intravenous sedation; (p = 0.02).
CONCLUSIONS: This retrospective analysis identified a significant association between the presence of long-term post-VV-ECLS psychiatric symptoms and the total number of days of intravenous sedation.
Volume
34
Issue
3
First Page
663
Last Page
667
ISSN
1532-8422
Published In/Presented At
McDonald, M. D., Lane-Fall, M., Miano, T. A., Henry, M., Gallagher, C., Hadler, R., Laudanski, K., Mackay, E. J., Usman, A. A., & Gutsche, J. (2020). The Effect of Sedation on Long-Term Psychological Impairment After Extracorporeal Life Support. Journal of cardiothoracic and vascular anesthesia, 34(3), 663–667. https://doi.org/10.1053/j.jvca.2019.07.147
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
31445835
Department(s)
Department of Anesthesiology
Document Type
Article