Dilated cardiomyopathy with mitral regurgitation: decreased survival despite a low frequency of left ventricular thrombus.
Publication/Presentation Date
9-1-1991
Abstract
Ninety-one patients with dilated cardiomyopathy were studied by two-dimensional, pulsed, and color Doppler echocardiography (1) to detect and quantify mitral regurgitation (MR), (2) to record apical flow velocities in systole and diastole, and (3) to detect the presence of left ventricular thrombi. MR was detected in 57% of the patients and thrombi were present in 40%, but the occurrence of both MR and thrombus was rare (8%). Apical flow velocity was significantly higher throughout the cardiac cycle in the group with MR (diastole 15 +/- 7 vs 9 +/- 7 cm/sec; systole 29 +/- 12 vs 16 +/- 13 cm/sec; p less than 0.001 for both), accounting for the rarity of thrombi in this group. Follow-up data on 89% of the patients showed markedly decreased survival in the group with MR (22% vs 60% at 32 +/- 6 months, p less than 0.005), and this was evident even in patients with mild MR. Thus although MR is a noninvasively obtainable marker of a large subgroup of patients with dilated cardiomyopathy "protected" from left ventricular thrombus formation, it is a sensitive marker of decreased survival.
Volume
122
Issue
3 Pt 1
First Page
763
Last Page
771
ISSN
0002-8703
Published In/Presented At
Blondheim, D. S., Jacobs, L. E., Kotler, M. N., Costacurta, G. A., & Parry, W. R. (1991). Dilated cardiomyopathy with mitral regurgitation: decreased survival despite a low frequency of left ventricular thrombus. American heart journal, 122(3 Pt 1), 763–771. https://doi.org/10.1016/0002-8703(91)90523-k
Disciplines
Medicine and Health Sciences
PubMedID
1877453
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article