Role of acetaminophen in acute myocardial infarction.
Publication/Presentation Date
6-1-2006
Abstract
Acetaminophen, the active ingredient in Tylenol, is a widely used drug that is well known for its analgesic and antipyretic properties. Acetaminophen is a commonly used alternative to nonsteroidal anti-inflammatory drugs, which have recently been demonstrated to increase mortality after acute myocardial infarction (AMI). The safety and potential cardioprotective properties of acetaminophen in the setting of AMI have recently been investigated; however, the results from these studies have been inconclusive. Using both large (ovine) and small (rabbit) collateral-deficient animal models, we studied the effects of acetaminophen in the setting of reperfused AMI. In both species we studied the effects of acetaminophen on myocardial salvage and ventricular function. Additionally, we studied the effects of acetaminophen on myocardial perfusion in sheep and on myocyte apoptosis in rabbits. Sixteen sheep and twenty-two rabbits were divided into two groups and administered acetaminophen or a vehicle before undergoing ischemia and reperfusion. The ischemic period was 60 min in sheep and 30 min in rabbits. All animals were reperfused for 3 h. There were no significant differences observed in myocardial perfusion, myocyte apoptosis, or infarct size in acetaminophen-treated animals. Acetaminophen increased cardiac output and mean arterial pressure before ischemia in sheep but had no effect on any other hemodynamic parameter. In rabbits, no effect on cardiac output or blood pressure was detected. These results support the role of acetaminophen as a safe drug in the postmyocardial infarction setting; however, no significant cardioprotective effect of the drug could be demonstrated.
Volume
290
Issue
6
First Page
2424
Last Page
2431
ISSN
0363-6135
Published In/Presented At
Leshnower, B. G., Sakamoto, H., Zeeshan, A., Parish, L. M., Hinmon, R., Plappert, T., Jackson, B. M., Gorman, J. H., 3rd, & Gorman, R. C. (2006). Role of acetaminophen in acute myocardial infarction. American journal of physiology. Heart and circulatory physiology, 290(6), H2424–H2431. https://doi.org/10.1152/ajpheart.00962.2005
Disciplines
Medicine and Health Sciences
PubMedID
16687610
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article