Benefit and risk evaluation of quinapril hydrochloride.
Publication/Presentation Date
4-15-2023
Abstract
INTRODUCTION: Angiotensin-converting enzyme (ACE) inhibitors are a mainstay of antihypertensive therapy. Quinapril hydrochloride, a less commonly used, and less-studied ACE inhibitor has been approved for its primary use in hypertension. Studies also indicate its off-label use for congestive heart failure and diabetic nephropathy. The ANDI and TREND trials have been pivotal in demonstrating the effectiveness of quinapril.
AREAS COVERED: The authors conducted a review of the literature analyzing the clinical efficacy and safety profile of quinapril. This review discusses the development of quinapril, provides an updated summary of the indications and contraindications, and presents a comparison with other ACE inhibitors.
EXPERT OPINION: Quinapril is a safe and well-tolerated antihypertensive medication with a favorable safety profile compared to other ACE inhibitors. However, a lack of ample recent clinical trials and post-marketing data investigating the efficacy of quinapril in large cohorts has resulted in limited use in clinical practice. Quinapril may be an effective antihypertensive option for elderly populations as well as those who cannot tolerate the side effects profiles of other ACE inhibitors and as an additional treatment option for patients with heart failure with preserved ejection fraction.
ISSN
1744-764X
Published In/Presented At
Barkhordarian, M., Lawrence, J. A., Ulusan, S., Erbay, M. I., Aronow, W. S., & Gupta, R. (2023). Benefit and risk evaluation of quinapril hydrochloride. Expert opinion on drug safety, 10.1080/14740338.2023.2203481. Advance online publication. https://doi.org/10.1080/14740338.2023.2203481
Disciplines
Medicine and Health Sciences
PubMedID
37060355
Department(s)
Department of Medicine, Cardiology Division, Fellows and Residents
Document Type
Article