Association of QRS duration and outcomes after myocardial infarction: the VALIANT trial.

Publication/Presentation Date

3-1-2006

Abstract

BACKGROUND: Prolongation of the QRS duration has been shown to be associated with adverse outcomes among heart failure (HF) patients. The association of QRS duration with clinical outcomes in the post-myocardial infarction (MI) setting is less well defined.

OBJECTIVES: To assess the prognostic significance of QRS duration prolongation on initial electrocardiogram after acute MI.

METHODS: QRS duration was measured in 403 patients with MI complicated by left ventricular dysfunction, signs or symptoms of HF, or both, who were enrolled in the Valsartan in Acute Myocardial Infarction (VALIANT) echo study. The cohort was divided into quartiles of QRS duration (<75 >ms, 75-88 ms, 89-108 ms, >108 ms). The number of clinical events were determined and compared across the groups.

RESULTS: Increasing QRS duration is associated with a higher incidence of HF, sudden death (SD), and cardiovascular (CV) death (P-trend

CONCLUSIONS: Prolonged QRS duration, even within the normal range, is associated with larger ventricular volumes, reduced systolic function, and an increased risk for development of HF, SD, and CV death after MI but appears to be a marker, rather than an independent predictor, for increased risk.

Volume

3

Issue

3

First Page

313

Last Page

316

ISSN

1547-5271

Disciplines

Medicine and Health Sciences

PubMedID

16500304

Department(s)

Cardiology Division

Document Type

Article

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