Publication/Presentation Date

12-1-2021

Abstract

Reports of cardiac arrhythmia secondary to loperamide toxicity have become increasingly common in the literature. We present two patients in their mid-20s, each having overdosed on loperamide and subsequently manifesting life-threatening cardiac arrhythmias not otherwise explained by known pathology. An analysis of the limited research available indicates that loperamide's capacity to block ion channels may be responsible for these events. A better mechanistic understanding of loperamide's effects can help inform clinical management of patients with these life-threatening symptoms as at this time no set guidelines for management have yet been established.

Volume

13

Issue

12

First Page

20744

Last Page

20744

ISSN

2168-8184

Disciplines

Medicine and Health Sciences

PubMedID

35111436

Department(s)

Department of Medicine, Cardiology Division

Document Type

Article

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