Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies.
Publication/Presentation Date
3-4-2026
Abstract
There is a need to develop safer, more efficient, and targeted strategies for the delivery of retinal gene therapies. Current strategies may require high dose therapeutics administered intravitreally or complex subretinal surgical delivery with increased risks. An optimized material carrier could enable localized delivery of therapeutics without extensive surgery. Here, we report a novel material carrier formed by octadecane-poly(ethylene glycol)-octadecane (OPO) molecules. OPO molecules were synthesized
ISSN
2050-7518
Published In/Presented At
Westbay, J. H., Bigley, D. P., Sappa, S., Ayalon, A., Aweidah, H., Dignam, L. D., Martel, J. N., Beltran, W. A., Sahel, J. A., Byrne, L. C., & DiLeo, M. V. (2026). Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies. Journal of materials chemistry. B, 10.1039/d6tb00267f. Advance online publication. https://doi.org/10.1039/d6tb00267f
Disciplines
Medicine and Health Sciences
PubMedID
41778383
Department(s)
Medical Education
Document Type
Article