The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif.
Publication/Presentation Date
6-24-2019
Abstract
Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecular platform to scaffold all the components of the PI3K-Akt pathway and results in the sequential generation of phosphatidylinositol-3,4,5-trisphosphate (PI3,4,5P
Volume
9
Issue
1
First Page
9126
Last Page
9126
ISSN
2045-2322
Published In/Presented At
Chen, M., Choi, S., Jung, O., Wen, T., Baum, C., Thapa, N., Lambert, P. F., Rapraeger, A. C., & Anderson, R. A. (2019). The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif. Scientific reports, 9(1), 9126. https://doi.org/10.1038/s41598-019-45671-5
Disciplines
Medicine and Health Sciences
PubMedID
31235839
Department(s)
Medical Education
Document Type
Article