Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions.

Authors

• Sandhya Chandrasekaran
• Sergio Espeso-Gil
• Yong-Hwee Eddie Loh
• Behnam Javidfar
• Bibi Kassim
• Yueyan Zhu
• Yuan Zhang
• Yuhao Dong
• Lucy K Bicks
• Haixin Li
• Prashanth Rajarajan
• Cyril J Peter
• Daijing Sun
• Esperanza Agullo-Pascual
• Marina Iskhakova
• Molly Estill
• Bluma J Lesch
• Li Shen
• Yan Jiang
• Schahram Akbarian

Publication/Presentation Date

12-13-2021

Abstract

Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic B

Volume

12

Issue

1

First Page

7243

Last Page

7243

ISSN

2041-1723

Published In/Presented At

Chandrasekaran, S., Espeso-Gil, S., Loh, Y. E., Javidfar, B., Kassim, B., Zhu, Y., Zhang, Y., Dong, Y., Bicks, L. K., Li, H., Rajarajan, P., Peter, C. J., Sun, D., Agullo-Pascual, E., Iskhakova, M., Estill, M., Lesch, B. J., Shen, L., Jiang, Y., & Akbarian, S. (2021). Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions. Nature communications, 12(1), 7243. https://doi.org/10.1038/s41467-021-26862-z

Disciplines

Medicine and Health Sciences

PubMedID

34903713

Department(s)

Medical Education

Document Type

Article