HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model.

Authors

• Alice K Min
• Behnam Javidfar
• Roy Missall
• Donald Doanman
• Madel Durens
• Mara Graziani
• Annika Mordelt
• Samuele G Marro
• Lotje de Witte
• Benjamin K Chen
• Talia H Swartz
• Schahram Akbarian

Publication/Presentation Date

12-21-2023

Abstract

Our mouse model is a powerful tool for investigating the genetic mechanisms governing central nervous system (CNS) human immunodeficiency virus type-1 (HIV-1) infection and latency in the CNS at a single-cell level. A major advantage of our model is that it uses induced pluripotent stem cell-derived microglia, which enables human genetics, including gene function and therapeutic gene manipulation, to be explored

Volume

97

Issue

12

First Page

0159523

Last Page

0159523

ISSN

1098-5514

Published In/Presented At

Min, A. K., Javidfar, B., Missall, R., Doanman, D., Durens, M., Graziani, M., Mordelt, A., Marro, S. G., de Witte, L., Chen, B. K., Swartz, T. H., & Akbarian, S. (2023). HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model. Journal of virology, 97(12), e0159523. https://doi.org/10.1128/jvi.01595-23

Disciplines

Medicine and Health Sciences

PubMedID

38032195

Department(s)

Medical Education

Document Type

Article