Common genetic variation in humans impacts
Publication/Presentation Date
9-21-2020
Abstract
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant inter-individual variability. In addition to showing more disease in males, the elderly, and individuals with underlying comorbidities, SARS-CoV-2 can seemingly render healthy individuals with profound clinical complications. We hypothesize that, in addition to viral load and host antibody repertoire, host genetic variants also impact vulnerability to infection. Here we apply human induced pluripotent stem cell (hiPSC)-based models and CRISPR-engineering to explore the host genetics of SARS-CoV-2. We demonstrate that a single nucleotide polymorphism (rs4702), common in the population at large, and located in the 3'UTR of the protease FURIN, impacts alveolar and neuron infection by SARS-CoV-2
ISSN
2692-8205
Published In/Presented At
Dobrindt, K., Hoagland, D. A., Seah, C., Kassim, B., O'Shea, C. P., Iskhakova, M., Fernando, M. B., Deans, P. J. M., Powell, S. K., Javidfar, B., Murphy, A., Peter, C., Møeller, R., Garcia, M. F., Kimura, M., Iwasawa, K., Crary, J., Kotton, D. N., Takebe, T., Huckins, L. M., … Brennand, K. J. (2020). Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection. bioRxiv : the preprint server for biology, 2020.09.20.300574. https://doi.org/10.1101/2020.09.20.300574
Disciplines
Medicine and Health Sciences
PubMedID
32995783
Department(s)
Medical Education
Document Type
Article