tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice.

Authors

• Jennifer Blaze
• Caleb J Browne
• Rita Futamura
• Behnam Javidfar
• Venetia Zachariou
• Eric J Nestler
• Schahram Akbarian

Publication/Presentation Date

7-1-2024

Abstract

DNA cytosine methylation has been documented as a potential epigenetic mechanism of transcriptional regulation underlying opioid use disorder. However, methylation of RNA cytosine residues, which would drive another level of biological influence as an epitranscriptomic mechanism of gene and protein regulation has not been studied in the context of addiction. Here, we probed whether chronic morphine exposure could alter tRNA cytosine methylation (m

Volume

49

Issue

8

First Page

1276

Last Page

1284

ISSN

1740-634X

Published In/Presented At

Blaze, J., Browne, C. J., Futamura, R., Javidfar, B., Zachariou, V., Nestler, E. J., & Akbarian, S. (2024). tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 49(8), 1276–1284. https://doi.org/10.1038/s41386-024-01813-6

Disciplines

Medicine and Health Sciences

PubMedID

38332016

Department(s)

Medical Education

Document Type

Article