The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Publication/Presentation Date
8-1-2017
Abstract
We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologically associated 1.2-Mb domain conserved in humans and mice that encompasses >70 genes at the clustered protocadherin locus (hereafter referred to as cPcdh). The cPcdh topologically associated domain (TAD
Volume
49
Issue
8
First Page
1239
Last Page
1250
ISSN
1546-1718
Published In/Presented At
Jiang, Y., Loh, Y. E., Rajarajan, P., Hirayama, T., Liao, W., Kassim, B. S., Javidfar, B., Hartley, B. J., Kleofas, L., Park, R. B., Labonte, B., Ho, S. M., Chandrasekaran, S., Do, C., Ramirez, B. R., Peter, C. J., C W, J. T., Safaie, B. M., Morishita, H., Roussos, P., … Akbarian, S. (2017). The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature genetics, 49(8), 1239–1250. https://doi.org/10.1038/ng.3906
Disciplines
Medicine and Health Sciences
PubMedID
28671686
Department(s)
Medical Education
Document Type
Article