An Unusual Progression of Bazex Syndrome (Acrokeratosis Paraneoplastica).
Publication/Presentation Date
4-1-2026
Abstract
Acrokeratosis paraneoplastica, also known as Bazex syndrome, is a rare paraneoplastic psoriasiform dermatosis that is strongly associated with squamous cell carcinoma (SCC) of mainly the head and neck. The disease typically progresses through three stages, initially affecting the fingernails, nose, and ears before spreading to the palms, soles, and eventually the trunk. We present an unusual progression of a psoriasiform rash in which the dorsal hands, trunk, and legs were primarily affected before involving the palmar hands and ears in a patient later diagnosed with oral SCC. This case also highlights the importance of maintaining a high index of suspicion for paraneoplastic conditions that could lead to more prompt diagnoses of internal malignancies and improve patient outcomes.
Volume
18
Issue
4
First Page
106783
Last Page
106783
ISSN
2168-8184
Published In/Presented At
Kahn, B., Van Noord, B. C., Skedros, S., Louis, D., & Goodman, M. B. (2026). An Unusual Progression of Bazex Syndrome (Acrokeratosis Paraneoplastica). Cureus, 18(4), e106783. https://doi.org/10.7759/cureus.106783
Disciplines
Medicine and Health Sciences
PubMedID
42117000
Department(s)
Medical Education
Document Type
Article