Nonmechanical Small Bowel Obstruction in a Patient on Zepbound Without a Surgical History: A Case Report.
Publication/Presentation Date
8-1-2025
Abstract
We present the case of a 52-year-old woman who developed a functional small bowel obstruction despite having no history of abdominal surgery, prior bowel obstruction, or GI interventions. The only notable recent change in her medical history was a dose escalation of Zepbound (tirzepatide), a glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide agonist prescribed for weight loss. This case raises concern about potential severe GI motility complications associated with Zepbound, particularly in the absence of conventional SBO risk factors.
Volume
17
Issue
8
First Page
90657
Last Page
90657
ISSN
2168-8184
Published In/Presented At
Lorenz, N., Stauffer, J., Abouafech, A., Mourad, A., & Bray, K. (2025). Nonmechanical Small Bowel Obstruction in a Patient on Zepbound Without a Surgical History: A Case Report. Cureus, 17(8), e90657. https://doi.org/10.7759/cureus.90657
PubMedID
40978855
Department(s)
Medical Education
Document Type
Article