Deep Vein Thrombosis-Induced Systemic Inflammation Triggering an Acute Polyarticular Gout Flare: A Case Report.
Publication/Presentation Date
10-1-2025
Abstract
Deep vein thrombosis (DVT) and gout are traditionally regarded as distinct conditions, yet emerging evidence suggests important inflammatory and clinical connections. We present a 40-year-old man with a history of crystal-proven gout who developed a left gastrocnemius DVT after prolonged travel, followed shortly by a severe polyarticular gout flare. Laboratory studies revealed marked hyperinflammation (C-reactive protein peaking at 87.8 mg/L) and a new positive antinuclear antibody titer (1:320, homogeneous). Arthrocentesis confirmed monosodium urate crystals, while magnetic resonance imaging demonstrated synovitis, a cartilaginous loose body, and degenerative changes. Coordinated care among hematology, rheumatology, and orthopedics involved anticoagulation management, intra-articular corticosteroid injection, and tailored anti-inflammatory therapy. This case illustrates how thromboinflammatory cytokines and oxidative stress accompanying DVT may precipitate acute gout, even in the absence of marked hyperuricemia. Recognizing this interplay is essential for timely diagnosis, safe therapeutic decision-making in the setting of anticoagulation, and ongoing surveillance for autoimmune disease.
Volume
17
Issue
10
First Page
95458
Last Page
95458
ISSN
2168-8184
Published In/Presented At
Abouafech, A., Oar, D. P., Mahon, H., & Bhagratie, J. (2025). Deep Vein Thrombosis-Induced Systemic Inflammation Triggering an Acute Polyarticular Gout Flare: A Case Report. Cureus, 17(10), e95458. https://doi.org/10.7759/cureus.95458
PubMedID
41306163
Department(s)
Medical Education
Document Type
Article