CT-based tissue segmentation to assess knee joint inflammation and reactive bone formation assessed by
Publication/Presentation Date
1-1-2018
Abstract
OBJECTIVE: This study was conducted to determine the role of computed tomography (CT)-based segmentation methodology to semi-quantify the degree of inflammation and reactive bone formation in the knee joints by fluorine-18-fluorodeoxyglucose (
SUBJECTS AND METHODS: In this retrospective study, we examined a total of 97 subjects who had undergone both
RESULTS: Fluorine-18-FDG uptake in the soft tissues surrounding the joint was 0.35±0.07 while 0.19±0.04 in the osseous structures (P< 0.0001). Aging positively correlated with
CONCLUSION: The PET-based molecular imaging probes along with the CT-based segmentation techniques revealed an association between aging and the inflammatory activity of the soft tissue compartment. Similarly, a positive correlation was noted between BMI and inflammation and reactive bone f ormation of the knee joint compartments.
Volume
21
Issue
2
First Page
102
Last Page
107
ISSN
1790-5427
Published In/Presented At
Al-Zaghal, A., Yellanki, D. P., Ayubcha, C., Werner, T. J., Høilund-Carlsen, P. F., & Alavi, A. (2018). CT-based tissue segmentation to assess knee joint inflammation and reactive bone formation assessed by 18F-FDG and 18F-NaF PET/CT: Effects of age and BMI. Hellenic journal of nuclear medicine, 21(2), 102–107. https://doi.org/10.1967/s002449910801
Disciplines
Medicine and Health Sciences
PubMedID
30006643
Department(s)
Medical Education
Document Type
Article