Eruptive Acral Melanocytic Lesions Associated With Capecitabine.
Publication/Presentation Date
8-19-2026
Abstract
Eruptive nevi and lentigines have been reported to occur in the setting of immunosuppression, which may be medication-induced. The associated histopathologic findings have not been well described in the literature. Herein, we report the case of a woman in her 60s who had been receiving chemotherapy treatment with capecitabine, a prodrug of 5-fluorouracil, for advanced pancreatic cancer. She developed multiple small, dark macules on the dorsal and plantar surfaces of both feet. An initial biopsy of one lesion showed a crowded lentiginous proliferation of predominantly single melanocytes, with poor nest formation and some pagetoid scatter. Subsequent biopsies revealed lentigines with melanocytic hyperplasia, which showed less cellularity than the initial biopsy. This case provides histopathologic correlation for eruptive acral melanocytic lesions that result from capecitabine therapy.
ISSN
1600-0560
Published In/Presented At
Smith, M., Jin, A., Miles, J. A., Elenitsas, R., DeHoratius, D. M., & Chu, E. Y. (2026). Eruptive Acral Melanocytic Lesions Associated With Capecitabine. Journal of cutaneous pathology, 10.1111/cup.70197. Advance online publication. https://doi.org/10.1111/cup.70197
Disciplines
Medicine and Health Sciences
PubMedID
42618550
Department(s)
Medical Education
Document Type
Article