Comparison of
Publication/Presentation Date
11-1-2020
Abstract
AIM: To compare the effects of high-dose therapy (HDT consisting of high-dose chemotherapy followed by autologous stem cell transplantation) and conventional-dose chemotherapy (non-HDT) on the uptake of
METHOD: The data of 19 MM patients who received HDT (61.5 (SD 5.6) years) and 11 MM patients who received conventional-dose chemotherapy (70.9 (SD 7.2) years) were collected in a prospective study. NaF PET/CT imaging was performed at baseline, and 8 weeks and 2 weeks after treatment for the HDT group and the non-HDT group, respectively. A CT-based algorithm was applied to segment the bones, and the global mean SUV (GSUVmean) of the whole bone and pelvis was calculated (OsiriX MD v.9.0, Pixmeo SARL; Bernex, Switzerland). In addition, regions of interest for the whole, medial, and lateral femoral neck were delineated bilaterally. Whole bone and pelvis measurements were replicated by two observers.
RESULTS: The average GSUVmean in the whole bone and pelvis of the patients who underwent HDT significantly decreased from before to after treatment (- 16.27%, p = 0.02 and - 16.54%, p = 0.01, respectively). A significant decrease in the whole and lateral femoral neck was also observed bilaterally in the HDT group. No significant decrease in average GSUVmean was observed in the non-HDT group. A high level of inter-observer reliability was found in intra-class correlation (ICC for pre-treatment whole bone 0.983, post-treatment whole bone 0.989, pre-treatment whole pelvis 0.998, post-treatment whole pelvis 0.996).
CONCLUSION: NaF uptake significantly decreased after treatment in patients who received high-dose therapy. A high level of agreement was observed between two operators for whole bone and pelvis measurements.
Volume
47
Issue
12
First Page
2846
Last Page
2855
ISSN
1619-7089
Published In/Presented At
Zirakchian Zadeh, M., Østergaard, B., Raynor, W. Y., Revheim, M. E., Seraj, S. M., Acosta-Montenegro, O., Ayubcha, C., Yellanki, D. P., Al-Zaghal, A., Nielsen, A. L., Constantinescu, C. M., Gerke, O., Werner, T. J., Zhuang, H., Abildgaard, N., Høilund-Carlsen, P. F., & Alavi, A. (2020). Comparison of 18F-sodium fluoride uptake in the whole bone, pelvis, and femoral neck of multiple myeloma patients before and after high-dose therapy and conventional-dose chemotherapy. European journal of nuclear medicine and molecular imaging, 47(12), 2846–2855. https://doi.org/10.1007/s00259-020-04768-0
Disciplines
Medicine and Health Sciences
PubMedID
32246208
Department(s)
Medical Education
Document Type
Article