Cutaneous cytomegalovirus in mixed serostatus kidney transplant patient.
Publication/Presentation Date
1-1-2025
Abstract
Cutaneous cytomegalovirus infection is a rare but serious complication in solid organ transplant recipients. We present a 47-year-old male kidney transplant recipient with a chronic, nonhealing right lower extremity ulcer. Initial biopsies revealed septic vasculopathy, leading to treatment with sodium thiosulfate and antibiotics for suspected calciphylaxis. Despite regular wound care, the ulcer continued to worsen. After completing 6 months of cytomegalovirus prophylaxis, surveillance viral levels remained undetectable, but the ulcer progressed considerably. Worsening severity prompted hospitalization, during which cytomegalovirus viremia was detected, and an ulcer biopsy confirmed cytomegalovirus inclusion bodies. Antiviral therapy was reinitiated, resulting in rapid and sustained wound improvement. Therefore, this case underscores cytomegalovirus' potential for cutaneous invasion in transplant recipients, even without preceding viremia, and highlights the importance of considering cutaneous cytomegalovirus in nonhealing ulcers posttransplant, especially in serodiscordant recipients.
Volume
13
First Page
2050313
Last Page
2050313
ISSN
2050-313X
Published In/Presented At
Finan, D., Garg, V., Lang, L., Royer, T., Belden, K., & Yang, S. (2025). Cutaneous cytomegalovirus in mixed serostatus kidney transplant patient. SAGE open medical case reports, 13, 2050313X251341511. https://doi.org/10.1177/2050313X251341511
Disciplines
Education | Medical Education
PubMedID
40433627
Department(s)
Department of Education
Document Type
Article