Tumor Location of Uveal Melanoma and Impact on Metastasis-Free Survival in 1001 Cases.
Publication/Presentation Date
8-1-2025
Abstract
BACKGROUND: There is limited literature on tumor location of uveal melanoma (UM) and the relative impact on metastasis-free survival (MFS).
METHODS: A review of 1001 consecutive eyes with UM was performed and precise tumor location was identified according to quadrant (5 zones), clock hour (13 zones), anteroposterior (5 zones), and a combination of clock hour and anteroposterior regions (49 zones). Heat maps were constructed for frequency in each zone and Kaplan-Meier estimates for 5- and 10-year MFS was calculated.
RESULTS: The UM quadrant regions included central (macula and juxtapapillary) (18%), superior (19%), nasal (18%), inferior (18%), and temporal (27%). The central region demonstrated smaller UM thickness (
CONCLUSIONS: Across all fundus regions, UM occurred most often in the central region. Uveal melanoma in the central region was smaller in thickness and base and demonstrated more favorable MFS compared to other quadrants, clock hours, and anteroposterior zones. Analysis of the 49 zones showed no benefit of tumor location alone after adjusting for tumor size and proximity to foveola and optic disc.
Volume
40
Issue
6
First Page
564
Last Page
574
ISSN
1744-5205
Published In/Presented At
Shields, C. L., Woods, M., Calotti, R., Evans, H., Medina, R., Mina, S., Pena, J. E., Khan, A., Nguyen, H., Bansal, R., Sener, H., Lally, S. E., & Shields, J. A. (2025). Tumor Location of Uveal Melanoma and Impact on Metastasis-Free Survival in 1001 Cases. Seminars in ophthalmology, 40(6), 564–574. https://doi.org/10.1080/08820538.2025.2507750
Disciplines
Education | Medical Education
PubMedID
40388212
Department(s)
Department of Education
Document Type
Article