Microfluidic Approaches and Methods Enabling Extracellular Vesicle Isolation for Cancer Diagnostics.

Authors

Premanshu Kumar Singh
Aarti Patel
Anastasia Kaffenes
Catherine Hord
Delaney Kesterson
Shaurya Prakash

Publication/Presentation Date

1-16-2022

Abstract

Advances in cancer research over the past half-century have clearly determined the molecular origins of the disease. Central to the use of molecular signatures for continued progress, including rapid, reliable, and early diagnosis is the use of biomarkers. Specifically, extracellular vesicles as biomarker cargo holders have generated significant interest. However, the isolation, purification, and subsequent analysis of these extracellular vesicles remain a challenge. Technological advances driven by microfluidics-enabled devices have made the challenges for isolation of extracellular vesicles an emerging area of research with significant possibilities for use in clinical settings enabling point-of-care diagnostics for cancer. In this article, we present a tutorial review of the existing microfluidic technologies for cancer diagnostics with a focus on extracellular vesicle isolation methods.

Volume

13

Issue

1

ISSN

2072-666X

Published In/Presented At

Singh, P. K., Patel, A., Kaffenes, A., Hord, C., Kesterson, D., & Prakash, S. (2022). Microfluidic Approaches and Methods Enabling Extracellular Vesicle Isolation for Cancer Diagnostics. Micromachines, 13(1), 139. https://doi.org/10.3390/mi13010139

Disciplines

Education | Medical Education

PubMedID

35056304

Department(s)

Department of Education

Document Type

Article