Survival with one versus three centimeters of active decompression during automated head-up CPR in a porcine cardiac arrest model.
Publication/Presentation Date
3-1-2026
Abstract
BACKGROUND: Automated head-up (AHUP) CPR, combining controlled head/thorax elevation, active compression-decompression CPR, and an impedance threshold device, has shown improved survival with favorable neurological outcomes versus conventional (C) CPR. The optimal amount of active lift (AD) during AHUP-CPR to optimize survival remains unknown. This study focused primarily on 24-h survival with 1-cm of active lift (AL-1 cm) with a rectilinear waveform versus 3-cm of active lift (AL-3 cm) with a trapezoidal waveform during AHUP-CPR.
METHODS: Anesthetized pigs (
RESULTS: ROSC occurred in 6/12 pigs with AL-1 cm vs 12/12 with AL-3 cm (
CONCLUSION: 24-h survival rates were significantly higher with AL-3 cm vs AL-1 cm during AHUP-CPR. Together with improved hemodynamics observed with AL-3 cm, these outcomes underscore the critical importance of AL-3 cm to optimize AHUP-CPR.
Volume
28
First Page
101231
Last Page
101231
ISSN
2666-5204
Published In/Presented At
Pourzand, P., Metzger, A., Moore, J., Salverda, B., Hai, H., Suresh, M., Bubier, S., Bachista, K., Segond, N., Debaty, G., & Lurie, K. (2026). Survival with one versus three centimeters of active decompression during automated head-up CPR in a porcine cardiac arrest model. Resuscitation plus, 28, 101231. https://doi.org/10.1016/j.resplu.2026.101231
Disciplines
Medicine and Health Sciences
PubMedID
41658278
Department(s)
Department of Emergency Medicine, Department of Emergency Medicine Residents, Fellows and Residents
Document Type
Article