Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice.

Authors

• David R Garcia Castro
• Joseph R Mazuk
• Erin M Heine
• Daniel Simpson
• R Seth Pinches
• Caroline Lozzi
• Kathryn Hoffman
• Phillip Morrin
• Dylan Mathis
• Maria V Lebedev
• Elyse Nissley
• Kang Hoo Han
• Tyler Farmer
• Diane E Merry
• Qiang Tong
• Maria Pennuto
• Heather L Montie

Publication/Presentation Date

8-18-2023

Abstract

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD

Volume

26

Issue

8

First Page

107375

Last Page

107375

ISSN

2589-0042

Published In/Presented At

Garcia Castro, D. R., Mazuk, J. R., Heine, E. M., Simpson, D., Pinches, R. S., Lozzi, C., Hoffman, K., Morrin, P., Mathis, D., Lebedev, M. V., Nissley, E., Han, K. H., Farmer, T., Merry, D. E., Tong, Q., Pennuto, M., & Montie, H. L. (2023). Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice. iScience, 26(8), 107375. https://doi.org/10.1016/j.isci.2023.107375

Disciplines

Medicine and Health Sciences

PubMedID

37599829

Department(s)

Department of Emergency Medicine

Document Type

Article