Physiological changes after deflation of Resuscitative Endovascular Balloon Occlusion of the Aorta following Automated Head-up Position Cardiopulmonary Resuscitation: a post-hoc analysis.

Publication/Presentation Date

7-1-2026

Abstract

BACKGROUND: Use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) and the automated head-up position (AHUP) have increasingly both been separately reported during cardiopulmonary resuscitation (CPR). The optimal hemodynamic management of REBOA balloon deflation after the return of spontaneous circulation (ROSC) is unknown. We hypothesized that partial deflation of REBOA rather than full deflation after ROSC would result in better hemodynamic parameters.

METHODS: After 10 min of untreated ventricular fibrillation, AHUP-CPR was performed on 20 pigs (weighting ∼40 kg). After 36 min, a REBOA balloon was inflated. After ROSC (13 pigs) REBOA deflation was initiated in one of two ways: complete (100%) or partial (50%) deflation. The primary endpoint was mean difference in mean aortic pressure (MAP) compared one minute before and one minute after REBOA deflation. Secondary endpoints were mean difference in cerebral perfusion (CerPP) and coronary perfusion (CorPP) pressures (in mmHg). Data were compared using Mann-Whitney

RESULTS: After ROSC the mean difference in MAP before and after deflation was 38.5 mmHg (95%CI: 17.0-60.0) with complete deflation versus 7.0 (95%CI: 1.8-12.3) with partial deflation (

CONCLUSION: In this porcine model of prolonged AHUP-CPR, partial REBOA balloon deflation resulted in superior hemodynamics compared with complete deflation.

Volume

30

First Page

101370

Last Page

101370

ISSN

2666-5204

Disciplines

Medicine and Health Sciences

PubMedID

42290699

Department(s)

Department of Emergency Medicine, Fellows and Residents

Document Type

Article

Link to Full Text

Share

COinS