Nicotine and Delta(9)-tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala.
Publication/Presentation Date
3-1-2009
Abstract
The central nucleus of the amygdala plays a key role in mediating aversive responses to drug withdrawal, effects thought to contribute to continued drug use. In previous studies, we found that the immediate early gene Narp, which encodes a secreted protein that binds to AMPA receptors, is induced in this nucleus following opiate withdrawal. Furthermore, Narp deletion alters the acquisition and extinction of aversive conditioning induced by opiate withdrawal. We now report that Narp is also induced in the central nucleus following withdrawal from other drugs of abuse, nicotine and Delta(9)-tetrahydrocannabinol, indicating that Narp is a common component of the transcriptional response triggered by drug withdrawal.
Volume
63
Issue
3
First Page
252
Last Page
255
ISSN
1098-2396
Published In/Presented At
Reti, I. M., Han, S., Miskimon, M., Rosen, J. B., & Baraban, J. M. (2009). Nicotine and Delta(9)-tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala. Synapse (New York, N.Y.), 63(3), 252–255. https://doi.org/10.1002/syn.20586
Disciplines
Medicine and Health Sciences
PubMedID
19084905
Department(s)
Department of Emergency Medicine
Document Type
Article