Lamotrigine ODT-Induced Seizure in a 3-Year-Old Child after Accidental Ingestion.

Ashley Griswold DO, Lehigh Valley Health Network
Briana Tully, Lehigh Valley Health Network
Kenneth D. Katz MD, Lehigh Valley Health Network
Gillian A. Beauchamp MD, Lehigh Valley Health Network
Matthew D. Cook DO, Lehigh Valley Health Network
Robert D. Cannon DO, Lehigh Valley Health Network

Abstract

Lamotrigine is a new generation antiepileptic which blocks sodium channels and can cause significant toxicity in overdose. A case of a three-year-old child who suffered a seizure and required endotracheal intubation after accidental lamotrigine ingestion is presented. The lamotrigine concentration measured 23.2 mcg/mL which is the highest reported after accidental pediatric exposure. A review of the literature regarding pediatric lamotrigine poisoning is also included.