Combined Parietal-Insular-Striatal Cortex Stroke with New-Onset Hallucinations: Supporting the Salience Network Model of Schizophrenia.
Publication/Presentation Date
1-1-2020
Abstract
Brain imaging studies have identified multiple neuronal networks and circuits in the brain with altered functioning in patients with schizophrenia. These include the hippocampo-cerebello-cortical circuit, the prefrontal-thalamic-cerebellar circuit, functional integration in the bilateral caudate nucleus, and the salience network consisting of the insular cortex, parietal anterior cingulate cortex, and striatum, as well as limbic structures. Attributing psychotic symptoms to any of these networks in schizophrenia is confounded by the disruption of these networks in schizophrenic patients. Such attribution can be done with isolated dysfunction in any of these networks with concurrent psychotic symptoms. We present the case of a patient who presents with new-onset hallucinations and a stroke in brain regions similar to the salience network (insular cortex, parietal cortex, and striatum). The implication of these findings in isolating psychotic symptoms of the salience network is discussed.
Volume
2020
First Page
4262050
Last Page
4262050
ISSN
2314-4327
Published In/Presented At
Nanda, S., Priya, K., Khan, T., Patel, P., Azizi, H., Nuthalapati, D., Paul, C., Sippy, R., Simsam, A. H., Abraham, J., Singh, G., Goodarzi, A., Ojimba, C., & Jolayemi, A. (2020). Combined Parietal-Insular-Striatal Cortex Stroke with New-Onset Hallucinations: Supporting the Salience Network Model of Schizophrenia. Psychiatry journal, 2020, 4262050. https://doi.org/10.1155/2020/4262050
Disciplines
Medicine and Health Sciences
PubMedID
32047802
Department(s)
Department of Family Medicine Residents, Fellows and Residents
Document Type
Article