Bleeding complications in acute liver failure.

Publication/Presentation Date

5-1-2018

Abstract

UNLABELLED: In patients with acute liver failure (ALF), elevated prothrombin time and thrombocytopenia can fuel a perception of a bleeding tendency. However, the incidence, site, risk factors, and clinical significance of bleeding complications have not been quantified in a large cohort of patients with ALF. We studied 1,770 adult patients enrolled in the ALF Study Group Registry between 1998 and 2016. Bleeding complications and blood component transfusions were collected for 7 days after admission. The relationship of bleeding complications to 21-day mortality was assessed. Despite a median international normalized ratio of 2.7 and platelet count of 96 × 10

CONCLUSIONS: Despite a perceived bleeding diathesis, clinically significant bleeding is uncommon in patients with ALF; bleeding complications in patients with ALF are markers of severe systemic inflammation rather than of coagulopathy and so portend a poor prognosis. (Hepatology 2018;67:1931-1942).

Volume

67

Issue

5

First Page

1931

Last Page

1942

ISSN

1527-3350

Disciplines

Medicine and Health Sciences

PubMedID

29194678

Department(s)

Department of Family Medicine, Department of Family Medicine Residents

Document Type

Article

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