Genome-Wide Analysis in

Mariann M Gabrawy
Nick Khosravian
George Morcos MD, Lehigh Valley Health Network
Tatiana V Morozova
Meagan Jezek
Jeremy D Walston
Wen Huang
Peter M Abadir
Jeff Leips


Despite impressive results in restoring physical performance in rodent models, treatment with renin-angiotensin system (RAS) inhibitors, such as Lisinopril, have highly mixed results in humans, likely, in part, due to genetic variation in human populations. To date, the genetic determinants of responses to drugs, such as RAS inhibitors, remain unknown. Given the complexity of the relationship between physical traits and genetic background, genomic studies which predict genotype- and age-specific responses to drug treatments in humans or vertebrate animals are difficult. Here, using 126 genetically distinct lines of