Hematopoietic stem cell mobilization following PD-1 blockade: Cytokine release syndrome after transplantation managed with ascorbic acid.
Publication/Presentation Date
8-1-2019
Abstract
Checkpoint inhibitor therapy is effective in the treatment of relapsed classical Hodgkin's Lymphoma. Here, we report a patient with relapsed Hodgkin's Lymphoma who received nivolumab prior to autologous stem cell mobilization. She went on to develop cytokine storm shortly following transplantation, with marked T-cell proliferation coincident with myeloid engraftment. Non-cardiogenic pulmonary edema and alveolar hemorrhage developed despite corticosteroid therapy. There was rapid and complete resolution of these complications with parenteral ascorbic acid infusion. Our case illustrates the risk of cytokine release syndrome following infusion of stem cells mobilized after checkpoint inhibitor therapy and the role of ascorbic acid in its management.
Volume
103
Issue
2
First Page
134
Last Page
136
ISSN
1600-0609
Published In/Presented At
Sindel, A., Taylor, T., Chesney, A., Clark, W., Fowler, A. A., 3rd, & Toor, A. A. (2019). Hematopoietic stem cell mobilization following PD-1 blockade: Cytokine release syndrome after transplantation managed with ascorbic acid. European journal of haematology, 103(2), 134–136. https://doi.org/10.1111/ejh.13248
Disciplines
Medicine and Health Sciences
PubMedID
31140644
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article