Reduced plasma ascorbic acid levels in recipients of myeloablative conditioning and hematopoietic cell transplantation.

Publication/Presentation Date

10-1-2019

Abstract

Hematopoietic cell transplantation (HCT) conditioned using myeloablative conditioning (MAC) is complicated by end organ injury due to endothelial dysfunction and graft versus host disease. Mucositis and oxidant injury results in micronutrient deficiency. Ascorbic acid (AA) levels were measured in 15 patients undergoing HCT conditioned with MAC (11 allogeneic and four autologous HCT). Ascorbate levels declined postconditioning to 27.3 μMol/L (±14.1) by day 0 (P = .03 compared with pretransplant baseline), reaching a nadir level of 21.5 (±13.8) on day 14 (P = .003) post-transplant. Patients undergoing allogeneic HCT continued to have low AA levels to day 60 post-transplant. The role of AA in maintaining endothelial function and hematopoietic as well as T-cell recovery is provided, developing the rationale for repletion of vitamin C following HCT.

Volume

103

Issue

4

First Page

329

Last Page

334

ISSN

1600-0609

Disciplines

Medicine and Health Sciences

PubMedID

31267566

Department(s)

Department of Medicine, Hematology-Medical Oncology Division

Document Type

Article

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