Adrenocortical carcinoma arising from an adrenal adenoma in a young adult female.
Adrenocortical carcinoma (ACC) is a rare malignancy that often carries a poor prognosis whereas adrenal incidentalomas are relatively common findings on imaging. Although most adrenal lesions are benign, 15% of patients with ACC are diagnosed based on workup for an adrenal incidentaloma. Continued surveillance or surgical resection may be recommended depending on size. The risk of a benign, non-functional adrenal lesion becoming malignant is low. Therefore, adrenal lesions typically undergo surveillance for no more than 2 years in patients with stable findings and no history of malignancy. This case describes a young adult female with a benign left adrenal adenoma who was found to have high grade ACC 7 years later. Based on interval size increase with indeterminate density, patient underwent surgical resection with adjuvant radiation and medical therapy.
Published In/Presented At
Rebielak, M. E., Wolf, M. R., Jordan, R., & Oxenberg, J. C. (2019). Adrenocortical carcinoma arising from an adrenal adenoma in a young adult female. Journal of surgical case reports, 2019(7), rjz200. https://doi.org/10.1093/jscr/rjz200
Medicine and Health Sciences
Hematology-Medical Oncology Division