Short- and Long-term Metabolic Exposure Data as Predicators of Coronary Microvascular Dysfunction in a Positron Emission Tomography Myocardial Perfusion Imaging (PET-MPI) Cohort with Near Concurrent Angiography.
Publication/Presentation Date
3-3-2026
Abstract
BackgroundCoronary microvascular disease (CMD) is defined by impaired myocardial stress flow reactivity and is associated with worse cardiovascular outcomes. Studying CMD is complicated by the overlap of its risk factors and patient-important cardiovascular sequelae with those of epicardial atherosclerotic disease. Published studies have not yet used longitudinal data to investigate the time dependencies of dynamic processes like obesity in their effects on microvascular health.Methods and ResultsIn a mixed-sex cohort of 85 patients for whom epicardial obstruction was angiographically excluded, a multivariate model was developed to measure strengths of association between repeated-measurement metabolic data and microvascular stress flow reactivity as assessed by position emission tomography myocardial perfusion imaging (PET-MPI). Body mass index and the diagnosis of insulin-dependent diabetes mellitus were associated with CMD on clinically meaningful scales when analyzing all metabolic data collected in the year prior to stress PET-MPI (β [95%CI]: -0.019 [-0.033,-0.0051],
First Page
1
Last Page
8
ISSN
1366-5804
Published In/Presented At
Van Galen, J., Ratcliffe, S. J., & Bourque, J. (2026). Short- and Long-term Metabolic Exposure Data as Predicators of Coronary Microvascular Dysfunction in a Positron Emission Tomography Myocardial Perfusion Imaging (PET-MPI) Cohort with Near Concurrent Angiography. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 1–8. Advance online publication. https://doi.org/10.1080/1354750X.2026.2639408
Disciplines
Medicine and Health Sciences
PubMedID
41773779
Department(s)
Hematology-Medical Oncology Division
Document Type
Article