The MEMORY Study: MulticentEr study of Minimally invasive surgery versus Open Radical hYsterectomy in the management of early-stage cervical cancer: Survival outcomes.

Authors

• Mario M Leitao, Memorial Sloan Kettering Cancer Center
• Qin C Zhou, Memorial Sloan Kettering Cancer Center
• Benny Brandt, Memorial Sloan Kettering Cancer Center
• Alexia Iasonos, Memorial Sloan Kettering Cancer Center
• Vasileios Sioulas, Memorial Sloan Kettering Cancer Center
• Katherine Lavigne Mager, Memorial Sloan Kettering Cancer Center
• Mark Shahin, Abington Jefferson Hospital
• Shaina Bruce, Abington Jefferson Hospital
• Destin R Black, Willis-Knighton Physician Network
• Carrie G Kay, Willis-Knighton Physician Network
• Meeli Gandhi, Willis-Knighton Physician Network
• Maira Qayyum, Willis-Knighton Physician Network
• Jennifer Scalici, University of South Alabama Mitchell Cancer Institute
• Nathaniel L Jones, University of South Alabama Mitchell Cancer Institute
• Rajesh Paladugu, University of South Alabama Mitchell Cancer Institute
• Jubilee Brown, Levine Cancer Institute
• R Wendel Naumann, Levine Cancer Institute
• Monica D Levine, Levine Cancer Institute
• Alberto Mendivil, Hoag Cancer Center
• Peter C Lim, University of Nevada School of Medicine
• Elizabeth Kang, University of Nevada School of Medicine
• Leigh A Cantrell, University of Virginia
• Mackenzie W Sullivan, University of Virginia
• Martin A. Martino MD, Lehigh Valley Health NetworkFollow
• Melissa Kratz RN, MSN, AOCN, Lehigh Valley Health NetworkFollow
• Valentin Kolev, Icahn School of Medicine
• Shannon Tomita, Icahn School of Medicine
• Charles A Leath, University of Alabama
• Teresa K L Boitano, University of Alabama
• David W Doo, University of Alabama
• Colleen Feltmate, Brigham and Women's Hospital
• Ronan Sugrue, Brigham and Women's Hospital
• Alexander B Olawaiye, University of Pittsburgh School of Medicine
• Ester Goldfeld, University of Pittsburgh School of Medicine
• Sarah E Ferguson, Princess Margaret Cancer Centre/University Health Network
• Jessa Suhner, Mount Sinai West/Mount Sinai Morningside
• Nadeem R Abu-Rustum, Memorial Sloan Kettering Cancer CenterFollow

Publication/Presentation Date

7-22-2022

Abstract

OBJECTIVE: The Laparoscopic Approach to Cervical Cancer (LACC) trial found that minimally invasive radical hysterectomy compared to open radical hysterectomy compromised oncologic outcomes and was associated with worse progression-free survival (PFS) and overall survival (OS) in early-stage cervical carcinoma. We sought to assess oncologic outcomes at multiple centers between minimally invasive (MIS) radical hysterectomy and OPEN radical hysterectomy.

METHODS: This is a multi-institutional, retrospective cohort study of patients with 2009 FIGO stage IA1 (with lymphovascular space invasion) to IB1 cervical carcinoma from 1/2007-12/2016. Patients who underwent preoperative therapy were excluded. Squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinomas were included. Appropriate statistical tests were used.

RESULTS: We identified 1093 cases for analysis-715 MIS (558 robotic [78%]) and 378. OPEN procedures. The OPEN cohort had more patients with tumors >2 cm, residual disease in the hysterectomy specimen, and more likely to have had adjuvant therapy. Median follow-up for the MIS and OPEN cohorts were 38.5 months (range, 0.03-149.51) and 54.98 months (range, 0.03-145.20), respectively. Three-year PFS rates were 87.9% (95% CI: 84.9-90.4%) and 89% (95% CI: 84.9-92%), respectively (P = 0.6). On multivariate analysis, the adjusted HR for recurrence/death was 0.70 (95% CI: 0.47-1.03; P = 0.07). Three-year OS rates were 95.8% (95% CI: 93.6-97.2%) and 96.6% (95% CI: 93.8-98.2%), respectively (P = 0.8). On multivariate analysis, the adjusted HR for death was 0.81 (95% CI: 0.43-1.52; P = 0.5).

CONCLUSION: This multi-institutional analysis showed that an MIS compared to OPEN radical hysterectomy for cervical cancer did not appear to compromise oncologic outcomes, with similar PFS and OS.

ISSN

1095-6859

Published In/Presented At

Leitao MM Jr, Zhou QC, Brandt B, Iasonos A, Sioulas V, Lavigne Mager K, Shahin M, Bruce S, Black DR, Kay CG, Gandhi M, Qayyum M, Scalici J, Jones NL, Paladugu R, Brown J, Naumann RW, Levine MD, Mendivil A, Lim PC, Kang E, Cantrell LA, Sullivan MW, Martino MA, Kratz MK, Kolev V, Tomita S, Leath CA 3rd, Boitano TKL, Doo DW, Feltmate C, Sugrue R, Olawaiye AB, Goldfeld E, Ferguson SE, Suhner J, Abu-Rustum NR. The MEMORY Study: MulticentEr study of Minimally invasive surgery versus Open Radical hYsterectomy in the management of early-stage cervical cancer: Survival outcomes. Gynecol Oncol. 2022 Jul 22:S0090-8258(22)00434-6. doi: 10.1016/j.ygyno.2022.07.002. Epub ahead of print.

Disciplines

Medicine and Health Sciences

PubMedID

35879128

Department(s)

Hematology-Medical Oncology Division, Department of Obstetrics and Gynecology, Patient Care Services / Nursing

Document Type

Article