Pacemaking Activity in the Peripheral Nervous System: Physiology and Roles of Hyperpolarization Activated and Cyclic Nucleotide-Gated Channels in Neuropathic Pain.

Authors

• Fan Liu
• George Y Wuni
• Ronak Bahuva
• Muhammad Ahsan Shafiq
• Boula S Gattas
• Crystal N Ibetoh
• Eugeniu Stratulat
• Domonick K Gordon

Publication/Presentation Date

10-23-2020

Abstract

The most famous pacemaking activity found in the human body is in the cardiac system. However, pacemaking is also widely present in the nervous system. The ion channels responsible for the pacemaking activity are called hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. HCN channels are activated during hyperpolarization and create an inward current named I

Volume

12

Issue

10

First Page

11111

Last Page

11111

ISSN

2168-8184

Published In/Presented At

Liu, F., Wuni, G. Y., Bahuva, R., Shafiq, M. A., Gattas, B. S., Ibetoh, C. N., Stratulat, E., & Gordon, D. K. (2020). Pacemaking Activity in the Peripheral Nervous System: Physiology and Roles of Hyperpolarization Activated and Cyclic Nucleotide-Gated Channels in Neuropathic Pain. Cureus, 12(10), e11111. https://doi.org/10.7759/cureus.11111

Disciplines

Medicine and Health Sciences

PubMedID

33240707

Department(s)

Hematology-Medical Oncology Division

Document Type

Article