Molecular interactions leading to lipoprotein retention and the initiation of atherosclerosis.
Publication/Presentation Date
12-1-2004
Abstract
Atherosclerosis is distinguished by the accumulation of lipoprotein lipid within the arterial wall. An ionic interaction of positively charged regions of apolipoprotein (apo) B with matrix proteins, including proteoglycans, collagen, and fibronectin, is thought to initiate this process. Proteoglycans are complex glycoproteins containing highly negatively charged carbohydrate chains. These proteins are abundant in atherosclerosis lesions, and they associate with apoB-containing lipoproteins. Several specific regions of apoB may mediate this process. Other lipoprotein-associated proteins, including apoE and lipases, might also participate in this process. In addition, retention may occur via lipoprotein association with other matrix molecules or as a consequence of intra-arterial lipoprotein aggregation.
Volume
24
Issue
12
First Page
2211
Last Page
2218
ISSN
1524-4636
Published In/Presented At
Khalil, M. F., Wagner, W. D., & Goldberg, I. J. (2004). Molecular interactions leading to lipoprotein retention and the initiation of atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 24(12), 2211–2218. https://doi.org/10.1161/01.ATV.0000147163.54024.70
Disciplines
Medicine and Health Sciences
PubMedID
15472124
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article