Metabolic Pathways and Targets in Chondrosarcoma.

Authors

• Ida Micaily
• Megan Roche
• Mohammad Y Ibrahim
• Ubaldo Martinez-Outschoorn
• Atrayee Basu Mallick

Publication/Presentation Date

1-1-2021

Abstract

Chondrosarcomas are the second most common primary bone malignancy. Chondrosarcomas are characterized by the production of cartilaginous matrix and are generally resistant to radiation and chemotherapy and the outcomes are overall poor. Hence, there is strong interest in determining mechanisms of cancer aggressiveness and therapeutic resistance in chondrosarcomas. There are metabolic alterations in chondrosarcoma that are linked to the epigenetic state and tumor microenvironment that drive treatment resistance. This review focuses on metabolic changes in chondrosarcoma, and the relationship between signaling

Volume

11

First Page

772263

Last Page

772263

ISSN

2234-943X

Published In/Presented At

Micaily I, Roche M, Ibrahim MY, Martinez-Outschoorn U, Mallick AB. Metabolic Pathways and Targets in Chondrosarcoma. Front Oncol. 2021 Dec 6;11:772263. doi: 10.3389/fonc.2021.772263. PMID: 34938658; PMCID: PMC8685273.

Disciplines

Medicine and Health Sciences

PubMedID

34938658

Department(s)

Hematology-Medical Oncology Division

Document Type

Article