Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8.

Authors

• Ramakrishnan Kannan
• Xingxing Wang
• LaShae Nicholson
• Nancy Z Lin
• Elisa M Howard
• Atrayee Basu
• Ines Ingabire
• Yuichi Sekine
• Stephen M Strittmatter

Publication/Presentation Date

10-13-2025

Abstract

Adult CNS trauma frequently causes neuronal disconnection and persistent deficits due to failed axon regeneration. While model system screening has identified multiple candidate neural repair pathways, ApoE-LRP8 signaling is unique in being implicated clinically. Here, we show that cortical axon regeneration requires LRP8 and is modified by

ISSN

2692-8205

Published In/Presented At

Kannan R, Wang X, Nicholson L, Lin NZ, Howard EM, Basu A, Ingabire I, Sekine Y, Strittmatter SM. Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8. bioRxiv [Preprint]. 2025 Oct 13:2025.10.10.681747. doi: 10.1101/2025.10.10.681747. PMID: 41278832; PMCID: PMC12632883.

Disciplines

Medicine and Health Sciences

PubMedID

41278832

Department(s)

Hematology-Medical Oncology Division

Document Type

Article