Circulating tumor cells: evolving evidence and future challenges.
Publication/Presentation Date
11-1-2009
Abstract
Circulating tumor cells (CTCs) are rare malignant cells found in the peripheral blood that originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterize these cells. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. This review covers the different techniques available for isolation of CTCs, the clinical utility of CTCs in breast, prostate, and colon cancer, and future directions in this field.
Volume
14
Issue
11
First Page
1070
Last Page
1082
ISSN
1549-490X
Published In/Presented At
Dotan, E., Cohen, S. J., Alpaugh, K. R., & Meropol, N. J. (2009). Circulating tumor cells: evolving evidence and future challenges. The oncologist, 14(11), 1070–1082. https://doi.org/10.1634/theoncologist.2009-0094
Disciplines
Medicine and Health Sciences
PubMedID
19897536
Department(s)
Hematology-Medical Oncology Division
Document Type
Article