Progress in the development of prognostic and predictive markers for gastrointestinal malignancies.
Publication/Presentation Date
10-1-2007
Abstract
Gastrointestinal cancers remain a significant cause of morbidity and mortality. While increasing therapeutic options have improved outcomes for many patients, they have also complicated treatment decision-making. Unfortunately, most patients with advanced gastrointestinal malignancies die from their disease. Prognostic and predictive markers could improve treatment significantly by identifying patients who may or may not require a given therapy, and determining those most likely to benefit from a therapy. Candidates for such markers include blood antigens and circulating tumor cells, tumor enzyme and gene expression, and pharmacodynamic endpoints. In this review, we summarize reported and ongoing research to define and validate prognostic and predictive markers in gastrointestinal malignancies, with an emphasis on colorectal cancer and brief overview of pancreatic and neuroendocrine tumors.
Volume
8
Issue
5
First Page
339
Last Page
351
ISSN
1527-2729
Published In/Presented At
Denlinger, C. S., & Cohen, S. J. (2007). Progress in the development of prognostic and predictive markers for gastrointestinal malignancies. Current treatment options in oncology, 8(5), 339–351. https://doi.org/10.1007/s11864-007-0045-x
Disciplines
Medicine and Health Sciences
PubMedID
18193357
Department(s)
Hematology-Medical Oncology Division
Document Type
Article