Drug development in pancreatic cancer: finally, biology begets therapy.
Publication/Presentation Date
1-1-2002
Abstract
Pancreatic cancer is rarely curable, and only 5% of patients achieve long-term survival. The vast majority of patients present with metastatic or unresectable disease. Standard chemotherapy with gemcitabine provides clinical benefit to only a small minority of patients. Thus, the development and investigation of new therapies is clearly needed. As knowledge of the underlying biology of pancreatic cancer has increased, targeted therapies based upon preclinical laboratory work have been developed, and are entering clinical trials. Some of these agents lack traditional dose-limiting toxicities (DLTs) at biologically active doses, and therefore clinical evaluation may not follow traditional guidelines for cytotoxic drug development. This article focuses on targeted therapies currently undergoing clinical evaluation in pancreatic cancer. Classes of therapeutics reviewed include those targeting tumor-microenvironment interactions (matrix metalloproteinase inhibitors, vascular endothelial growth-factor blockade), signal transduction (e.g., farnesyltransferase inhibitors), growth-factor receptors (epidermal growth-factor receptor blockade, Her-2/neu, gastrin), and vaccine approaches. Currently, there is a renewed optimism that the clinical application of biologic understanding will lead to an improved outcome for patients with pancreatic cancer.
Volume
32
Issue
2-3
First Page
91
Last Page
106
ISSN
1537-3649
Published In/Presented At
Cohen, S. J., & Meropol, N. J. (2002). Drug development in pancreatic cancer: finally, biology begets therapy. International journal of gastrointestinal cancer, 32(2-3), 91–106. https://doi.org/10.1385/IJGC:32:2-3:91
Disciplines
Medicine and Health Sciences
PubMedID
12794245
Department(s)
Hematology-Medical Oncology Division
Document Type
Article