Can molecular imaging predict response to preoperative chemoradiation in patients with rectal cancer? A Fox Chase Cancer Center prospective experience.
Publication/Presentation Date
12-1-2005
Abstract
This study was undertaken to correlate change in fluorine-18 fluorodeoxyglucose positron emission tomography ((18)FDG-PET) uptake with response to combined-modality neoadjuvant therapy in patients with locally advanced rectal cancer. Twenty patients (13 male; 7 female) underwent (18)FDG-PET scans before and 3 to 4 weeks after completion of chemoradiation before surgery. Staging by endoscopic ultrasound was T3/T4 (17/1); two patients were unable to undergo endorectal ultrasound. Fifteen patients had perirectal lymphadenopathy. Median radiation dose was 5,040 cGy (range, 4,500 to 5,500 cGy). All patients received continuous infusion 5-fluorouracil (or capecitabine) with radiation. Median pre- and post-chemoradiation standard uptake values were 9.4 (range, 3.6 to 37.0) and 3.05 (range, 0.5 to 8.2), respectively. Median percent standard uptake value decrease observed in the postchemoradiation PET scans was 71% (range, 7% to 95%). Six patients (30%) had pathologic complete response. Only two of six patients with postchemoradiation standard uptake values
Volume
32
Issue
6 Suppl 9
First Page
63
Last Page
67
ISSN
0093-7754
Published In/Presented At
Konski, A., Hoffman, J., Sigurdson, E., Haluszka, O., Engstrom, P., Cheng, J. D., Cohen, S. J., Watson, J. C., Eisenberg, D., McGarrity, E., Freedman, G., & Meropol, N. J. (2005). Can molecular imaging predict response to preoperative chemoradiation in patients with rectal cancer? A Fox Chase Cancer Center prospective experience. Seminars in oncology, 32(6 Suppl 9), S63–S67. https://doi.org/10.1053/j.seminoncol.2005.04.026
Disciplines
Medicine and Health Sciences
PubMedID
16399435
Department(s)
Hematology-Medical Oncology Division
Document Type
Article