Increased cerebral blood flow after leukapheresis for acute myelogenous leukemia.
Publication/Presentation Date
12-1-2007
Abstract
Leukapheresis is often considered in the management of acute myelogenous leukemia (AML) with hyperleukocytosis and its sequelae, including myocardial infarction, pulmonary complications, and stroke. It is utilized on the assumption that leukapheresis improves blood rheology. We present a woman with AML and a history of meningioma encasing her left internal carotid artery. She presented with hyperleukocytosis and symptoms of ischemia. As her white blood cell continued to rise despite initiation of hydroxyurea therapy, she underwent leukapheresis emergently. Transcranial Doppler ultrasound demonstrated increased flow velocities in the left internal carotid and the right middle cerebral arteries, which normalized after leukapheresis. This is the first documentation that leukapheresis, in combination with hydroxyurea, improves cerebral hemodynamics in a patient with AML.
Volume
82
Issue
12
First Page
1110
Last Page
1112
ISSN
0361-8609
Published In/Presented At
Kasner, M. T., Laury, A., Kasner, S. E., Carroll, M., & Luger, S. M. (2007). Increased cerebral blood flow after leukapheresis for acute myelogenous leukemia. American journal of hematology, 82(12), 1110–1112. https://doi.org/10.1002/ajh.21006
Disciplines
Medicine and Health Sciences
PubMedID
17654677
Department(s)
Hematology-Medical Oncology Division
Document Type
Article