The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome.

Authors

• Amanda McBride
• Sarah Houtmann
• Lindsay Wilde
• Carlos Vigil
• Christine M Eischen
• Margaret Kasner
• Neil Palmisiano

Publication/Presentation Date

1-1-2019

Abstract

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.

Volume

9

First Page

192

Last Page

192

ISSN

2234-943X

Published In/Presented At

McBride, A., Houtmann, S., Wilde, L., Vigil, C., Eischen, C. M., Kasner, M., & Palmisiano, N. (2019). The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome. Frontiers in oncology, 9, 192. https://doi.org/10.3389/fonc.2019.00192

Disciplines

Medicine and Health Sciences

PubMedID

30972300

Department(s)

Hematology-Medical Oncology Division

Document Type

Article